Last May I described the issue I had of massive files buildup in the cups folder of my early 2009 Mac Pro during printing from LR, filling the OWC 120 Gb SSD used just for applications:
http://forum.luminous-landscape.com/index.php?topic=100544.msg823431#msg823431. My solution is to just regularly delete those files.
Now, 2 days ago, I lost control of the optical mouse cursor. It would only move in the top left quadrant of the VGA monitor on my right and the top right quadrant of the Eizo CG243W on my left, with inability to steady the cursor on any point in those areas. I checked all connections, tried one monitor at a time, tried another mouse, went to Safe Mode and verified the disk and corrected permissions for that disk, ran the latest ClamX AV and attempted re-installation of Mavericks (that stalled, with '4 hours and 14 minutes remaining', and no progress after 12 hours). So to regain control of the cursor, in Safe Mode I enabled Mouse Keys under Accessibility Preferences, Mouse and Trackpad. That went fine but also, to my surprise, restored mouse control of the cursor, and all seems well again!
Even after helpful discussion here, I couldn't understand the cups files issue, and this latest problem with the cursor seems weird. I wonder if the SSD is starting to fail (although Disk Utility verified it OK), or what!
(Mac specs are: 2.66 GHz Quad-Core Intel Xeon, 16 GB 1066 MHz DDR3 ECC; ATI Radeon HD 4870 512 MB)