If you're photographing purely STATIC scenes/objects/subjects, then either option can work very well. However, if you are photographing people, animals, or anything that can't sit/remain absolutely still for 5 seconds up to multiple minutes at a time, I'd probably start looking at single shot solutions. Multi shot is great, and allows for superb color accuracy(as does the Betterlight backs), but the last few generations of 60/80mp digital backs(heck, even a used P45+ is a tremendous back, and are now somewhat "affordable" on the used market).
I too am a large format user, primarily with color film. I drum scan my selected frames, and usually start with files ranging from 400mb up to 1.5Gb, depending on format and scan dpi. If you are only shooting a small number of frames(compared to your b/w film work), why not just use color sheet film? The cost of film and scans(assuming you outsource for these) will allow you to spread the cost of such(vs swallowing a big chunk of change on a digital system) over a longer period of time.
If you're shooting high rates of reproduction and need the turnaround time only digital can deliver, then disregard my above comments
I'm using both 4x5 and 5x7, formerly 8x10.
cheers,
Dan