Surely it's time for a sanity check. What would the practical depth of field constraints be for an 18x or 20x enlargement?
There are two aspects to DoF. A scientific one based upon absolute resolution (ie. lp/mm of different parts of the scene) and a subjective one based upon an 'impression' from an appropriate viewing distance.
A consequence of lens improvement is that the parts of the image that are in focus will be sharper, but the parts of the scene 'not in focus' will
not be sharper. There is consequently a greater disparity between what's in focus and what's not in focus, and therefore an 'actual', lp/mm, scientific, shallower DoF.
This seems unavoidable. But I would question the sanity of anyone who expects out-of-focus parts of any image to be as sharp as in-focus parts. We all know there is only one plane of focus.
There are always technological means being developed to overcome such problems. If your pixels are too small to generate sufficient dynamic range, try filling and emptying them several times during one long exposure. If the scene itself is just too contrasty for even relatively large pixels, then employ AEB and blend the images in PS. If you have a conflict between DoF requirements and absolute resolution, ie. if you insist that 30x40" prints should have the same DoF close up as they do from a 'normal' viewing distance, then you will have to employ ADOFB (auto depth of field bracketing which hasn't been developed yet but no doubt will by the time we get 28MP 35mm sensors). There are already available programs that blend differently focussed images to create enormous DoF from the scientific lp/mm perspective. All that's required now is an automation of that process.
What back-breakingly heavy tripod would be required to still every last micron of vibration?
As BJL has implied, it's all to do with pixel count and FoV. As regards holding the camera steady, it makes little difference if we have 28mp on a 35mm sensors, a 2/3rds sensor 1/16th the area, or an MF sensor 4x the area. The camera has to be held equally steady for all formats, for the same FoV and pixel count. The sorts of things that will change the outcome, however, are vibrations from mirror slap and mechanical shutters. The EVF cameras with electronic shutters will have the advantage with extremely high pixel count sensors.
And if there's a growing sense of dissatisfaction now with Canon's wide angles, what would the feeling be when those same optics are scrutinised at massive enlargement scales?
It's always unfortunate when one aspect of technological development streaks ahead of another essential component in the system. One would hope that Canon's new lenses would be up to the task when they introduce their ultra-high pixel density FF 35mm cameras. Perhaps we might even be able to trust them
not to release a 28mp body until they've designed an appropriate lens. Who knows! Perhaps it depends on how savvy they think the camera buying public is.
There's an interesting analogy with Hi Fi audio here. For a long time now, amplifiers have exceeded the specifications of loudspeakers. Your sound quality is basically limited by the quality of your loudspeakers and your living room acoustics. You can spend as much on a state-of-the-art amplifier as on a Canon 1Ds2 body (and more). But any improvement with your existing loudspeakers in the same living room would be
less noticeably than the resolution improvement of a 20D over a D60.
It's the perrenial problem again. Things that have to interface with 'reality' (ie. outside controlled laboratory conditions) are really difficult to improve. There are too many variables.
I'm editing this post in order to have a liitle rant which I think is relevant. My latest computer was built about 6 months ago. A Pentium dual core 64 bit processor, 3 GB of RAM and 400GB of Hard Drive. It was supposed to be my main computer for editing and storing photos. It's a white elephant. My Xrite-DTP94 colormeter does not yet have a 64 bit driver. I cannot calibrate my Sony CRT monitor with my fastest and best computer because production of a 64 bit driver is too difficult for X-rite or ColorEyes. And this is essentially a laboratory situation; just the monitor, the video card and the software. Very disturbing!